Afoxin

Description Afoxin 500mg Tablet contains Clarithromycin (500mg), a macrolide antibiotic used to treat a wide range of bacterial infections. It works by stopping bacterial growth through inhibition of protein synthesis in bacterial cells. This medicine is also combined with anti-ulcer drugs to address certain stomach ulcers caused by Helicobacter pylori. Formulated as a film-coated tablet, it’s suitable for adults and children over 12 years who can swallow tablets, providing broad-spectrum coverage against gram-positive and some gram-negative bacteria.

Ingredients Clarithromycin 500mg.

Drug Class Macrolide Antibiotic / Anti-Bacterial.

Dosage Form Film-Coated Tablet (1×10’s pack).

Uses Afoxin Tablets are prescribed for relief from:

• Bacterial infections in the lower and upper respiratory tract.
• Bronchitis (lung inflammation).
• Skin and soft tissue infections (e.g., muscles, tendons).
• Acute otitis media (middle ear infection).
• Pharyngitis and tonsillitis (throat infections).
• Helicobacter pylori infections (stomach ulcers).
• Prevention of Mycobacterium avium complex (MAC) in immunocompromised patients.

Doctor’s Review Infectious disease specialists and general practitioners frequently prescribe Afoxin for its effective coverage against respiratory and skin pathogens. As one clinician observes: “Afoxin offers reliable treatment for common bacterial infections with good tissue penetration. It’s particularly useful in H. pylori eradication regimens, though monitoring for side effects is key in patients with organ impairment.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults & Children over 12 years: 500mg once or twice daily, depending on infection severity.
• For H. pylori triple therapy: 500mg twice daily with amoxicillin and a PPI (e.g., omeprazole) for 10-14 days.
• Renal impairment (CrCl <30ml/min): Reduce to 250mg once or twice daily.
• Take for the full course, even if symptoms improve.

In Case of Overdose Overdose may lead to severe gastrointestinal upset, liver toxicity, or QT prolongation. Seek immediate medical attention or contact a poison center. Supportive care includes monitoring heart rhythm, hydration, and activated charcoal if ingestion was recent. In severe cases, hemodialysis may help remove the drug.

Missed Dose Take as soon as remembered unless close to the next dose. Do not double up to avoid overdose risks like nausea or irregular heartbeat. Resume your regular schedule and consult your doctor if doses are frequently missed.

How to Use

• Swallow whole with water, with or without food; take with food or milk if stomach upset occurs.
• Space doses evenly (e.g., every 12 hours for twice-daily).
• Do not crush or chew extended-release forms.
• Complete the full course to prevent resistance.
• For best absorption, avoid antacids within 2 hours.

When Not to Use Avoid Afoxin if:

• Allergic to clarithromycin, other macrolides (e.g., erythromycin), or any excipients.
• History of cholestatic jaundice or liver dysfunction from prior clarithromycin use.
• Taking certain drugs like pimozide, ergotamines, or colchicine (due to interactions).
• Severe kidney impairment (CrCl <30ml/min) without dose adjustment.
• Clostridium difficile-associated diarrhea (current or recent).

Side Effects Common:

• Stomach upset, nausea, diarrhea, vomiting.
• Headache, taste changes.
• Abnormal liver tests.

Uncommon / Severe (Stop and seek medical help):

• Allergic reactions (rash, itching, swelling, anaphylaxis).
• Severe diarrhea (possible C. difficile infection).
• QT prolongation (irregular heartbeat, dizziness).
• Liver injury (jaundice, dark urine).
• Tingling, mouth/tongue inflammation.

Precautions & Warnings

• Stop use before allergy skin tests, as it may interfere with results.
• Use cautiously in liver or kidney disease; regular monitoring needed.
• May prolong QT interval—avoid in heart rhythm disorders.
• Risk of superinfections like oral thrush or C. difficile colitis.
• Inform your doctor of all medications to avoid interactions.

Drug Interactions

• QT-prolonging drugs (e.g., amiodarone, cisapride)—contraindicated.
• CYP3A4 substrates (e.g., statins, warfarin, digoxin)—may increase levels.
• Calcium channel blockers or theophylline—monitor closely.

Food Interactions

• Can be taken with or without meals; food reduces stomach upset.
• Avoid grapefruit juice, as it may alter drug levels.
• No major alcohol interactions, but avoid to prevent GI irritation.

Storage/Disposal

• Store at room temperature (15-30°C), away from heat, light, and moisture.
• Keep tightly closed and out of reach of children.
• Dispose via pharmacy take-back programs; do not flush.

Quick Tips

• Take at consistent times for steady levels.
• Stay hydrated to ease GI side effects.
• Probiotics may help prevent diarrhea.
• Report persistent symptoms to avoid resistance.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.