Cefiget DS

Cefixime 200mg syrup/suspension is a third-generation cephalosporin antibiotic that demonstrates bactericidal activity by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), disrupting peptidoglycan cross-linking essential for cell wall integrity, leading to bacterial lysis and death. This broad-spectrum action targets both Gram-positive and Gram-negative organisms, making it suitable for respiratory, urinary, and other susceptible bacterial infections while minimizing resistance development through targeted therapy.

Key Benefits:

• Effective against common respiratory pathogens
• Broad coverage for Gram-positive/Gram-negative bacteria
• Oral suspension ideal for pediatric and compliance-challenged patients
• Reduces infection spread and symptom duration
• Supports faster recovery from bacterial exacerbations
• Complements comprehensive infection management protocols

How to Use

• Administration: Shake bottle well before measuring; use provided oral syringe or marked cup for accurate dosing.
• Timing: Once or twice daily as prescribed; with or without food.
• Dosage: Per healthcare provider instructions; complete full course even if symptoms improve.
• Preparation: Reconstitute if powder form per label; discard unused portion after 14 days.
• Monitoring: Track symptom resolution; report persistence.

Expert Tips from CureCart Direct:

• Use precise measuring devices—avoid household spoons.
• Store reconstituted suspension in refrigerator; discard after expiry.
• Probiotics may help maintain gut flora; consult pharmacist.
• Complete therapy to prevent resistance; do not self-extend.
• Inform doctor of allergy history before starting.

Missed Dose: Take ASAP unless near next dose—skip and resume. Do not double; use reminders for consistency.

Overdose: May cause nausea, vomiting, diarrhea, dizziness, headache, confusion—seek immediate medical evaluation with dose details.

Primary Uses

• Treatment of bacterial respiratory infections (bronchitis, pneumonia).
• Management of ear, throat, and sinus infections.
• Control of bacterial growth and infection prevention.
• Relief from fever, cough, chest pain in respiratory infections.
• Acute exacerbations of chronic bronchitis.
• Uncomplicated urinary tract infections.
• Targeted therapy against susceptible strains to combat resistance.

Indications

Indicated for bacterial infections caused by susceptible organisms, including respiratory tract infections, otitis media, pharyngitis, and uncomplicated UTIs.

Side Effects

Common:

• Diarrhea, nausea, vomiting
• Abdominal pain or discomfort
• Headache, dizziness

Less Common:

• Skin rash, itching
• Vaginal yeast infection
• Fatigue

Serious/Rare:

• Severe allergic reactions (anaphylaxis)
• Clostridium difficile-associated diarrhea
• Seizures in predisposed patients

Monitor for persistent diarrhea or rash.

Warnings and Precautions

• Pregnancy/Lactation: Use if benefits outweigh risks; consult physician.
• Driving: May cause dizziness—avoid if affected.
• Renal Impairment: Dose adjustment needed; monitor function.
• GI History: Caution in colitis; watch for superinfections.
• Allergies: Cross-reactivity with penicillins possible.
• Resistance: Reserve for confirmed/suspected bacterial infections.
• Other: Complete course; probiotics for gut protection.

Contraindications

Do not use in:

• Known allergy to Cefixime or cephalosporins.
• History of severe penicillin reactions.
• Severe renal impairment or dialysis patients.
• Infants <6 months.
• GI diseases like colitis.
• Infections from resistant bacteria.
• Seizure/neurological disorder history.

Drug Interactions

• Probenecid: Increases Cefixime levels by reducing excretion.
• Other Antibiotics (carbapenems, aminoglycosides): Potential efficacy/side effect alterations.
• Oral Contraceptives: May reduce effectiveness; use backup.
• Antacids (Al/Mg): Decrease absorption; separate by 2 hours.
• Nephrotoxics (aminoglycosides, diuretics): Heightened kidney risk.
• Live Vaccines: May impair response.
• QT-Prolonging Drugs: Arrhythmia potential.

Food Interactions

• Limit dairy: Calcium reduces absorption.
• Avoid grapefruit: May elevate levels.
• Restrict alcohol: Potential liver effects.
• Skip high-fat meals: Delays absorption.
• Separate iron supplements/foods: Interference.
• Limit vitamin K greens: If on anticoagulants.
• Probiotics: Restore flora; timing per provider.

Storage/Disposal

Store at room temperature (20-25°C) away from light/moisture; refrigerate reconstituted suspension. Keep in original container, tightly sealed. Avoid bathroom/heat sources. Do not freeze. Discard expired/unused per pharmacist; no flushing/drain disposal. Childproof storage essential.

Doctor Review

Dr. Ayesha Khan, MBBS, FCPS – Infectious Disease Specialist “Cefixime 200mg suspension represents third-generation cephalosporin pharmacology through PBP binding that inhibits transpeptidation in peptidoglycan synthesis, achieving bactericidal concentrations against beta-lactamase producing Gram-negatives like Haemophilus and Moraxella. Its oral bioavailability supports outpatient respiratory and UTI management, with favorable pharmacokinetics showing peak serum levels within 3-4 hours and biliary/fecal elimination minimizing renal burden in mild impairment. Cross-reactivity concerns with penicillin allergy (5-10%) necessitate anaphylaxis history review, while C. difficile risk underscores probiotic co-administration and course completion to curb resistance selection in community pathogens.”

FAQs

How does Cefixime work? Inhibits cell wall synthesis via PBP binding, causing lysis.

Complete course necessary? Yes, prevents resistance and relapse.

Dairy interaction? Avoid; reduces absorption—take separately.

Allergy risk? High if penicillin-sensitive; inform doctor.

Pediatric use? Not <6 months; dose by weight.

Related Tests: Culture/sensitivity, renal function, CBC.

Quick Tips:

• Shake well; measure accurately.
• Refrigerate after mixing.
• Full course adherence.
• No sharing; child-safe storage.

Disclaimer: This information is for educational purposes only and not a substitute for professional medical advice. Always consult a qualified physician before use. CureCart Direct ensures accurate details but cannot cover all interactions or precautions. Prices and availability subject to change.