Pantra

Description Pantra IM/IV Injection 100mg/2ml contains Tramadol HCl (100mg per 2ml), a synthetic opioid analgesic used to manage moderate to severe pain. It acts on the central nervous system (brain and spinal cord) by binding to mu-opioid receptors and inhibiting norepinephrine and serotonin reuptake, altering pain perception and providing relief. This sterile solution is administered via intramuscular (IM) or intravenous (IV) routes, making it suitable for acute pain scenarios like post-operative or trauma-related discomfort where oral intake is not feasible. Each box includes 5 ampoules for convenient dosing in clinical settings.

Ingredients Tramadol HCl 100mg per 2ml ampoule.

Drug Class Opioid Analgesic / Centrally Acting Analgesic.

Dosage Form Solution for Injection (IM/IV; 1 box = 5 ampoules of 2ml each).

Uses Pantra IM/IV Injection is prescribed for:

• Relieving moderate to severe acute pain (e.g., post-surgical, injury-related).
• Managing chronic pain unresponsive to non-opioid analgesics.
• Preventing pain in anticipated scenarios (e.g., before procedures).
• Adjunct in multimodal pain therapy for inflammation-associated discomfort.
• Short-term use in hospital or outpatient settings for rapid onset.

Doctor’s Review Dr. Khalid Rehman, a pain management specialist in Lahore, values Pantra for its versatility: “Pantra 100mg IM/IV is a reliable rescue option for severe pain, offering quick relief via opioid and serotonin/norepinephrine pathways. Its injectable form is perfect for acute cases, but I always emphasize short-term use and monitoring for respiratory depression or addiction risks.”

Dosage (Follow physician’s instructions — typical guideline)

• Adults: Initial 50-100mg (1 ampoule) IM/IV every 4-6 hours as needed; max 400mg daily.
• Post-operative: 100mg IV bolus, followed by 50mg every 10-20 minutes if needed (total ≤250mg in first hour).
• Elderly or renal/hepatic impairment: Start at 50mg; max 200mg daily.
• Not for children under 12 years or post-tonsillectomy/adenoidectomy in under 18s.
• Infuse IV slowly over 2-3 minutes to avoid hypotension; IM in large muscle.

In Case of Overdose Overdose may cause respiratory depression, seizures, coma, or hypotension. Seek emergency medical attention immediately. Symptoms include severe drowsiness, slow breathing, or collapse. Treatment includes naloxone for reversal, supportive ventilation, and monitoring in an ICU setting.

Missed Dose Doses are typically scheduled by healthcare providers in acute settings, so misses are rare. If self-administered, take as soon as remembered unless close to the next dose—do not double up to avoid overdose risks like seizures. Consult your doctor to adjust the regimen.

How to Use

• Administer IM deep into large muscle (e.g., gluteus) or IV slowly over 2-3 minutes to prevent nausea or hypotension.
• Use aseptic technique; inspect ampoule for cracks or discoloration before use.
• Do not mix with other drugs in syringe; compatible with saline or dextrose for IV infusion.
• Discard unused portion after opening; store ampoules upright.
• Transition to oral Tramadol when possible for ongoing management.

When Not to Use Avoid Pantra if:

• Allergic to Tramadol HCl or excipients (symptoms: rash, itching, swelling, breathing difficulty).
• Acute porphyria or myotonic dystrophy.
• Severe respiratory depression or recent opioid use.
• Children under 12 years or post-tonsillectomy/adenoidectomy in under 18s.
• Concurrent use with MAO inhibitors (within 14 days).
• Uncontrolled epilepsy or severe head injury.

Side Effects Common:

• Dizziness, sedation, fatigue, headache.
• Constipation, nausea/vomiting, sweating, dry mouth.
• Indigestion, hiccups, appetite changes.

Uncommon / Severe (Stop and seek medical help):

• Skin reactions, sudden low blood pressure, collapse.
• Muscle weakness, tremor, seizures, respiratory depression.
• Mood improvement (euphoria), confusion, sleep disturbance, blurred vision.

Precautions & Warnings

• Inform your doctor of other medications (e.g., tranquilizers, antidepressants, opioids)—may increase drowsiness or seizure risk.
• Use short-term in patients with abuse history; monitor for tolerance (needing higher doses).
• Risk of convulsions higher with certain drugs (e.g., SSRIs, antipsychotics)—assess suitability.
• Monitor respiratory rate and sedation in elderly or impaired patients.
• Avoid abrupt stops to prevent withdrawal (anxiety, sweating, diarrhea).
• May impair driving or machinery—avoid until effects are known.

Drug Interactions

• Carbamazepine (e.g., Tegretol): Speeds Tramadol metabolism, reducing efficacy.
• Warfarin (e.g., Coumadin): Increases bleeding risk—monitor INR.
• Heart rhythm drugs: May prolong QT interval—monitor ECG.
• SSRIs/SNRIs, tricyclics, quinidine, phenothiazines, antipsychotics, ondansetron: Heighten serotonin syndrome or seizure risk.

Food Interactions

• Can take with or without food; no major restrictions.
• Avoid alcohol—amplifies sedation and respiratory depression.
• Grapefruit juice may alter metabolism—limit intake.
• Maintain consistent meals to prevent nausea.

Storage/Disposal

• Store at room temperature (15-30°C), away from direct light and heat.
• Keep ampoules in original box, out of reach of children and pets.
• Do not use if solution is cloudy or discolored; discard unused after opening.
• Dispose via medical waste protocols or pharmacy returns; do not flush.

Quick Tips

• Administer slowly IV to avoid nausea or low BP.
• Rise slowly to prevent dizziness from low pressure.
• Carry naloxone if prescribed for overdose reversal.
• Report seizures or breathing issues immediately.
• Use laxatives for constipation prevention.

Disclaimer This information is provided for educational purposes only and does not replace medical advice. Use only under the supervision of a licensed physician. Do not self-medicate.