Prostin E-2

Prostin E-2 vaginal tablets are strictly hospital-bound in Pakistani maternity wards, from Lady Reading Hospital in Peshawar to Jinnah Postgraduate Medical Centre in Karachi, where obstetricians insert them to ripen the cervix and kick off labor in overdue or medically needed cases. As dinoprostone (PGE2), it’s PMDC-regulated for induction only when fetal and maternal risks are low, with constant monitoring to dodge hyperstimulation or rupture—common in our high-parity births. A strip of 4x3mg from Pfizer costs PKR 1,500-2,000—hospital-only dispensing—pulled from ob-gyn protocols, doc insertion required.

Basic Product Details

• Form and Strength: Vaginal tablets, 3 mg dinoprostone each.
• Packaging: Box with 1 strip of 4 tablets.
• Pricing: PKR 1,500-2,000 per box, varies—strict hospital supply.
• Brands in Pakistan: Prostin E-2 from Pfizer, no common generics due to regulation.

Ingredients

• Active Ingredient: Dinoprostone 3 mg (prostaglandin E2).
• Excipients: Glycerides of saturated vegetable fatty acids—handle with gloves, wash after.

Drug Class

Prostaglandin E2 Analog (Oxytocic).

How It Functions

Dinoprostone hits uterine smooth muscle for contractions and ripens cervix by boosting endogenous PGE2/PGF2α, mimicking labor onset. In Pakistan’s late-term inductions, it’s for favorable cases, but docs watch for overkill in scarred uteri from multiple C-sections.

Common Applications

Local ob-gyn guidelines limit to:

• Labor induction at term with no contraindications.
• Cervical ripening for stalled progress.

Dosage Form

Vaginal tablets inserted high in posterior fornix by doc; 1 tablet, wait 6-8 hours for second if needed—max 6 mg/day.

Potential Side Effects

Common: Nausea, vomiting, diarrhea, vaginal warmth/itching.

Serious from reports: Uterine hyperstimulation, fetal distress, amniotic embolism (chest pain, breathlessness), placental abruption, rupture, fetal/neonatal death, maternal hypertension. ER for severe pain or bleeding.

Key Warnings and Precautions

PMDC mandates:

• Uterus: Risk of rupture—monitor contractions/fetal heart; stop if hypertonus.
• Handling: Gloves on, wash hands—skin absorption irritates.
• Pregnancy: For term only; causes abortion if early.
• Monitoring: Continuous CTG, cervical checks.
• Oxytocin: Wait 6 hours post-dose.

No for scarred uterus or multiples without caution.

When It’s Not Suitable (Contraindications)

Avoid if:

• Hypersensitive to prostaglandins.
• Fetal/maternal contraindications (e.g., placenta previa, prior C-section).
• Unfavorable cephalopelvic proportions.

Drug Interactions

Flag:

• Oxytocin—hyperstimulation up; space 6 hours.

In Case of Overdose

Excess contractions or fetal distress—remove tablet if possible, tocolytics, ER monitoring.

Missed Dose

Hospital-administered; no patient miss—doc manages.

Storage and Disposal

Refrigerate 2-8°C, don’t freeze; room temp brief. Hospital disposal for unused.

Quick Tips

• Lie supine 10-30 min post-insert.
• No self-admin; hospital only.
• Report pain or bleeding fast.

Doctor Review

Obstetricians at PIMS or SIUT use Prostin E-2 for elective inductions in post-term pregnancies with Bishop score <6, inserting 3mg vaginally with 4-hour checks, but favor Foley for multiparas and halt on tachysystole per local SOGP guidelines—fetal scalp pH if distress.

Laboratory Screening

Pre-use:

• Cephalopelvic assessment.
• Fetal well-being tests (NST, biophysical profile).

This maps Prostin E-2’s labor start in Pakistan—hospital facts, ob-gyn oversight.

Disclaimer: This is product information only, not a prescription or diagnosis. Consult a qualified Pakistani doctor before using Prostin E-2 tablets to ensure it’s safe. Seek immediate care for severe symptoms like chest pain, heavy bleeding, or contractions.