Risek Insta Sugar Free

Description

Risek Insta Sugar Free Sachets 40mg combine omeprazole and sodium bicarbonate to treat acid-related disorders like gastroesophageal reflux disease (GERD) in Pakistan. Omeprazole, a proton pump inhibitor, reduces stomach acid, while sodium bicarbonate neutralizes acid for faster relief. Widely used in urban centers like Lahore and Karachi, where spicy diets and stress aggravate reflux, it’s prescription-only, priced around Rs. 300-350 per box of 10 sachets, available in DRAP-registered pharmacies.

How It Functions

Omeprazole irreversibly blocks the H+/K+ ATPase enzyme (proton pump) in gastric parietal cells, reducing acid secretion by up to 90%, effective for both basal and stimulated acid production. Sodium bicarbonate acts as a buffer, raising stomach pH for quicker symptom relief. Chemically, omeprazole is 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; sodium bicarbonate is NaHCO3. Effects begin within 1 hour, peaking at 2 hours, lasting up to 24 hours.

Dosage Information

Adults: One sachet (40mg omeprazole + sodium bicarbonate) dissolved in water, taken orally once daily, preferably 1 hour before a meal. For GERD, erosive esophagitis, or maintenance of healed esophagitis, treatment lasts 4-8 weeks; symptomatic GERD may use shorter courses. Dose adjustments for liver or kidney issues; not for children unless specialist-directed. Follow medical guidance for duration to avoid overuse risks.

Side Effects

• Very Common (>1 in 10): Headache, diarrhea, constipation, abdominal pain, nausea, vomiting, flatulence.
• Common (up to 1 in 10): Dizziness, tingling, sleepiness, insomnia, vertigo, rash, itching, hives, malaise, elevated liver enzymes.
• Rare: Confusion, agitation, aggression, depression, hallucinations (in severely ill), gynecomastia, severe skin reactions (e.g., Stevens-Johnson syndrome), low sodium levels.

Drug Interactions

May interact with:

• Ketoconazole, itraconazole, posaconazole, erlotinib: Reduces absorption due to less acid.
• Diazepam, phenytoin, clomipramine: Slows metabolism, increasing drug levels.
• Clopidogrel: Reduces antiplatelet effect.
• Digoxin, saquinavir, tacrolimus, methotrexate: Increases levels, risking toxicity.
• Rifampicin, St. John’s wort: Lowers omeprazole efficacy.
• Nelfinavir: Avoid co-use; reduces antiviral effect.

Indications

Approved for adults to treat:

• Gastroesophageal reflux disease (GERD), including symptomatic relief.
• Erosive reflux esophagitis.
• Long-term management to prevent relapse in healed esophagitis.

When Not to Use

Avoid in:

• Hypersensitivity to omeprazole, substituted benzimidazoles, or excipients.
• Concomitant use with nelfinavir.
• Confirmed gastric malignancy without investigation.

Precautions

• Rule out gastric cancer before starting; symptom relief may mask malignancy.
• Use cautiously in liver disease; monitor liver enzymes.
• Sodium bicarbonate content requires caution in low-sodium diets, common in hypertensive Pakistanis.
• Monitor for low magnesium or potassium, especially with diuretics or long-term use.
• Avoid in pregnancy/breastfeeding without physician approval; limited data on fetal/infant safety.
• Buy from DRAP-registered pharmacies; check holograms to avoid counterfeits.

Warnings

• Atrophic gastritis: Long-term use may cause stomach lining changes; periodic endoscopy advised.
• Sodium overload: Avoid in Bartter’s syndrome, hypokalemia, respiratory alkalosis, or acid-base issues; risk of milk-alkali syndrome with calcium/milk.
• Bone health: Long-term use may increase fracture risk; monitor in elderly.
• Clostridium difficile: Risk of diarrhea; stop if severe or bloody stools occur.
• Kidney function: Monitor in chronic kidney disease to avoid sodium-related complications.

Additional Notes

• Pregnancy Category: Consult physician; category C, limited data, avoid unless essential.
• Breastfeeding: Small amounts in milk; monitor infant for side effects.
• Availability: Common in urban and rural pharmacies; generics like Omez available.
• Stability: Reconstituted sachet solution stable for 30 minutes; use immediately.
• Reporting: Log batch for side effects; report to DRAP for quality control.

Doctor Review

Dr. Salman Ahmed, a gastroenterologist in Karachi, notes Risek Insta’s rapid relief for GERD, popular among patients with spicy diets in Pakistan. DRAP data supports its efficacy in esophagitis, but Dr. Ahmed stresses checking for malignancy and monitoring sodium levels in heart patients to avoid complications.

Disclaimer

This is general product information, not a prescription or medical advice. Consult your doctor or pharmacist for personal guidance.